Notes Microbial Transformation of Griseofulvin by Cephalosporium C Ur Tipes
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چکیده
Wehave studied the microbial transformation of griseofulvin (I) by Cephalosporium curtipes and the formation of two more polar metabolites was observed in a proportion of 10:1. The compounds have been identified as (+)-5'-hydroxygriseofulvin (axial) (II) and G'-hydroxymethylgriseofulvin (III) (Fig. 1). The microbial transformation of griseofulvin was performed by a 48-hour-old culture of Cephalosporium curtipes strain. Cultivation was maintained on a rotary shaker (220r.p.m.) at 24°C in a medium having the following composition: 1.5%
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